Methionine Sulfoxide Reductase A (human) (rec.)

Product Description: Methione sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system, MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin (1), HIV protease (2) and a1-proteinase-inhibitor (3). Recent studies indicate that there is a connection between MsrA and Alzheimer's disease in mammals (4).

Alternate Names/Synonyms: PMSR; MSRA; EC=1.8.4.11; Peptide Met(O) Reductase; Protein-Methionine-S-Oxide Reductase; Peptide-Methionine (S)-S-Oxide Reductase, Mitochondrial Peptide Methionine Sulfoxide Reductase

Product type: Protein

Source / Host: E. coli

Species Crossreactivity: Human

SBiological Activity: 1.2U/mg (One unit will cause the oxidation of 1.0 µmole of NADPH at 25°C at pH7.5)

Purity: >95% (SDS-PAGE)

Concentration: 1 mg/ml

Formulation: Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: -20°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability:

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