anti-Methionine Sulfoxide Reductase A, mAb (5B5)

Product description: Monoclonal Antibody. Recognizes the Human, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and alpha1-proteinase-inhibitor (1-3). Recent studies indicate that there is a connection between MsrA and Alzheimer°s disease in mammals. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Alternate Names/Synonyms: MSRA; PMSR; EC=1.8.4.11; Peptide Met(O) Reductase; Protein-Methionine-S-Oxide Reductase; Peptide-Methionine (S)-S-Oxide Reductase, Mitochondrial Peptide Methionine Sulfoxide Reductase

Product Type: Monoclonal Antibody

Clone: 5B5

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: IHC, IP

Species Crossreactivity: Human, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Sun, H. et al. (1999) Biochemistry. 38, 105-112. (General)2) Davis, D. A. et al. (2000) Biochem. J. 346, 305-311. (General)3) Abrams, W. R. et al. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 7483-7486. (General)4) Gabbita, S. P. et al. (1999) J. Neurochem. 73, 1660-1666. (General)