anti-MKP4 (pk12), mAb (AF11B5)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP4 (DUSP9) is a dual specificity phosphatase, which acts as a negative regulator of insulin-stimulated pathways. MKP4 is expressed in kidney, placenta and adipose tissue. MKP4, a cytosolic MKP with specificity to not only Erk, but also, to a lesser extent, JNK and p38. MKP4 also reversed the effect of TNF-alpha to inhibit insulin Signaling. MKP4 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance. Inactivates MAP kinases. Has a specificity for the ERK family.

Alternate Names/Synonyms: MKP4; MKP-4; DUSP9; EC=3.1.3.16; EC=3.1.3.48; MAP Kinase Phosphatase 4; Dual Specificity Protein Phosphatase 9; Mitogen-activated Protein Kinase Phosphatase 4

Product Type: Monoclonal Antibody

Clone: AF11B5

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-MKP4 protein purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Keyse SM, (2008) Cancer Metastasis Rev 27(2):253-61. (General)2) Emanuelli B et al. (2008) Proc Natl Acad Sci 105(9):3545-50. (General)3) Christie GR et al. (2005) Mol Cell Biol 25(18):8323-33. (General)