anti-MPO (Myeloperoxidase), mAb (1A1)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Myeloperoxidase is a major neutrophil protein and is also present in monocytes. In neutrophils, it is stored in azurophilic granules and released during phagocytosis. It is a heme enzyme that uses the superoxide and hydrogen peroxide generated by the neutrophil oxidative burst to produce hypochlorous acid and other reactive oxidants.The produced hypochlorous acid reacts with and destroys bacteria. In many inflammatory pathologies, such as cystic fibrosis and rheumatoid arthritis, neutrophils are also causing tissue damage. MPO is thought to be the most promising cardiac marker at the moment. In addition to that MPO is a good inflammatory biomarker for autoimmune, inflammatory diseases and cancer. Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Alternate Names/Synonyms: MPO; EC=1.11.2.2

Product Type: Monoclonal Antibody

Clone: 1A1

Isotype: Mouse IgG1 kappa

Immunogen: Purified from human sputum.

Applications: ELISA, IP

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Winterbourn CC, et al, Curr Opin Hematol. (2000) vol.7(1): pp.53-8. (General)2) Hansson M, et al, Arch Biochem Biophys. (2006) vol.445(2): pp.214-24. (General)3) Nicholls SJ, Hazen SL. Arterioscler Thromb Vasc Biol. (2005) vol.25(6): pp.1102-11. (General)4) Klebanoff SJ. J Leukoc Biol. (2005) vol.77(5): pp.598-625. (General)