anti-MSK2, pAb

Product description: Polyclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Mitogen- and stress-activated protein kinases (MSK2) is nuclear kinase that act downstream of mitogen-activated protein/extracellular signal-regulated kinase pathways. It contains two kinase domains in the N-terminal and C-terminal region, respectively. MSK2 is activated in response to mitogenic stimuli via Erk1/2MAPK pathway and also by stress stimuli via p38MAPK pathway. Signals from mitogens and cellular stresses are involved in many functions including cell proliferation, differentiation, and survival through the phosphorylation of cyclic AMP response element-binding protein (CREB) at Ser133 which is catalyzed by MSK2. Recently, MSK2 has been shown to be required for stress-induced phosphorylation of histone H3-Ser and transcriptional activation of several immediate early genes. Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional activation of several immediate early genes, including proto-oncogenes FOS and JUN. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Alternate Names/Synonyms: MSK2; RSKB; RPS6KA4; S6K-alpha-4; EC=2.7.11.1; Ribosomal Protein Kinase B; Ribosomal Protein S6 Kinase alpha-4; 90 kDa Ribosomal Protein S6 Kinase 4; Nuclear Mitogen- and Stress-activated Protein Kinase 2

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: IHC, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Duncan EA et al, J Biol Chem. 2006; vol.281(18): pp.12521-5. (General)2) Soloaga A et al, EMBO J. 2003; vol.22(11) : pp.2788-97. (General)3) Wiggin GR et al, Mol Cell Biol. 2002; vol.22(8): pp.2871-81. (General)