anti-Neurosin, mAb (9A7)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Neurosin (KLK6), one of these, is atrypsin-like protease dominantly expressed in the human brain but also in a variety of other tissues. As measured by a sensitive quantitative assay in serum and cerebrospinal fluid(CSF), it may have value as a biomarker for diagnosis and monitoring of Alzheimer's disease (AD). It seems to be down regulated in serum and tissues of AD patients and may be involved in amyloid metabolism. Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Alternate Names/Synonyms: Zyme; KLK6; SP59; PRSS18; Neurosin; Protease M; EC=3.4.21.-; Kallikrein-6; Serine Protease 9; Serine Protease 18

Product Type: Monoclonal Antibody

Clone: 9A7

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Akira O, et. al. Neurochemistry (2001) vol.12(7) pp.1345 -50. (General)2) George M, et. al. Clinica Chimica Acta (2003) vol.329, pp.1-8. (General)3) Georgios P, et. al. BBRC (2004) vol.320 pp.54-61. (General)