anti-Noggin, pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Noggin is a 32°kDa glycoprotein that binds to bone morphogenetic protein (BMP) and antagonizes the action of them. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo. BMPs also regulate cell proliferation, differentiation, lineage determination, motility, and death. BMP antagonists include noggin, chordin, follistatin, ventroptin, twisted gastrulation, Dan, and gremlin etc. They play a crucial role in bone development, by regulating the BMP functions. Noggin plays a key role in neurulation by inhibiting BMP4, along with other morphogens such as chordin and follistatin and in the formation of the neural plate. Noggin inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. It antagonizes the action of BMPs, and induces neural tissue and dorsalizes ventral mesoderm. Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.

Alternate Names/Synonyms: NOG; Noggin

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: WB

Species Crossreactivity: Human, Mouse

Concentration: 1 mg/ml

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Chang KH et al. (2007) Circulation. 116:1258-1266. (General)2) Yanagita M, (2005) Cytokine Growth Factor Rev. 16(3):309-317. (General)3) Canalis E et al. (2003) Endocr Rev. 2003 24(2):218-235. (General)