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100 µl

Ref. YIF-LF-MA0362
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three distinct subunits, alpha, beta and gamma. Non Neuronal Enolase (ENO1) is an isoform of mammalian enolase and is composed of 2 alpha subunits. The gene for ENO1 also encodes a shorter monomeric structural lens protein, tau-crystallin. Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.

Alternate Names/Synonyms: NNE; ENO1; MPB-1; MBP-1; ENO1L1; Enolase 1; EC=4.2.1.11; alpha-Enolase; Non-Neural Enolase; Phosphopyruvate Hydratase; Plasminogen-binding Protein; C-Myc Promoter-binding Protein

Product Type: Monoclonal Antibody

Clone: 9F7

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human His-NNE protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Ray R. Miller D.M. (1991) Mol. Cell. Biol. 11:2154-2161. (General)2) Sugahara T. Et al. (1992) Cytotechnology 10:137-146. (General)3) Ghosh A.K. Et al. (1999) Mol. Cell. Biol. 19:2880-2886. (General)4) Feo S. Et al. (2000) FEBS Lett. 473:47-52. (General)5) Lopez-Alemany R. Et al (2004) Am.J. Hematol. 72:234-242. (General)6) Arza B. Et al. (1997) Thromb. Haemost. 78:1097-1103. (General)