anti-NSE (gamma Enolase), mAb (37E4)

Product description: Monoclonal Antibody. Recognizes the Human, Mouse protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three distinct subunits, alpha, beta and gamma. The gammagamma and alphagamma dimeric forms of enolase, referred to as neuron-specific enolase (NSE), are localized mainly in neurons and neuroectodermal tissue. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are injured. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival

Alternate Names/Synonyms: NSE; ENO2; Enolase 2; EC=4.2.1.11; gamma-Enolase; Neural Enolase; Neuron-specific Enolase; 2-Phospho-D-Glycerate Hydro-lyase

Product Type: Monoclonal Antibody

Clone: 37E4

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-gamma-enolase purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human, Mouse

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Fletcher, L. et al. (1976) Biochim. Biophys. Acta. 452(1), 245-252. (General)2) Lima, J.E. et al. (2004) J. Neurol. Sci. 217(1), 31-35. (General)3) Suzuki, Y. et al. (1999) Neurology 53(8), 1761-1764. (General)