AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Polyclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The three Rb (retinoblastoma) family proteins, p107, p130, and pRB, are also known as 'pocket proteins', after their conserved pocket region. Members of the family form part of a signal-transduction pathway called the Rb pathway, which is important in cell-cycle regulation and have roles in growth suppression, differentiation and apoptosis. The pocket domain is responsible for interaction with transcription factors, cyclins, and cyclin-dependent kinases (CDKs). They play crucial roles in the cell cycle through interaction with members of the E2F transcription factors family. They are acting on the cell cycle between G0 and S phases, primarily through binding and inactivation of transcription factors. The three pocket proteins consist of an amino-terminal domain, a pocket region composed of two conserved domains (A and B) separated by a spacer region, and a carboxy-terminal domain. The human RB gene (which encodes a protein of 105 kDa and is also called p105) was first identified when both familial and sporadic retinoblastoma, a form of malignant tumor of the retina. The retinoblastoma protein was originally described as a tumor suppressor, as it was found to be mutated in many forms of cancer. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Alternate Names/Synonyms: RB2; RBL2; p130; pRb2; RBR-2; Retinoblastoma-like Protein 2; Retinoblastoma-related Protein 2; 130 kDa Retinoblastoma-associated Protein
Product Type: Polyclonal Antibody
Immunogen: Synthetic peptide.
Species Crossreactivity: Human
Concentration: 1 mg/ml
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Claudio PP et al. (2002) Genome Biol. 3(9):reviews3012. (General)2) Classon M and Dyson N. (2001) Exp Cell Res. 264(1):135-147 (General)3) Hannon GH et al. (1993) Genes Dev. 7:2378-2391. (General)
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