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Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. p21, also known as cyclin-dependent kinase inhibitor 1A or CDKN1A, directly inhibits the activity of cyclin-cdk2 and cyclin-cdk4 complexes. It mainly inhibits the activity of cyclin/cdk2 complexes and negatively modulates cell cycle progression. p21 also plays other fundamental roles including transcriptional regulation and the modulation of apoptosis. p21 forms part of a family of structurally related proteins comprising p21, p27 and p57 that all share the ability to inhibit a wide range of cyclin -dependent kinase holoenzymes. Besides its cdk inhibitor function, p21 is recognized to play a wide variety of physiological roles, many of which rely on its nuclear localization. p21 can bind to proliferating cell nuclear antigen (PCNA) thereby blocking DNA synthesis. p21 functions as a regulator of cell cycle progression at S phase. The expression of p21 is controlled by the tumor suppressor protein p53. Each of these functions of p21 is achieved through direct p21/protein interactions and the subcellular localization of p21 plays an important part in dictating the binding partners to which p21 is exposed. May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
Alternate Names/Synonyms: p21; CAP20; MDA-6; CDKN1A; CDK-interacting Protein 1; Cyclin-dependent Kinase Inhibitor 1; Melanoma Differentiation-associated Protein 6
Product Type: Monoclonal Antibody
Isotype: Mouse IgG1 kappa
Immunogen: Recombinant human His-ABD-p21 protein purified from E. coli.
Applications: ELISA, WB
Species Crossreactivity: Human
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Child ES and Mann DJ, (2006) Cell Cycle 5(12):1313-9 (General)2) Liu G and Lozano G, (2005) Cancer Cell 7(2):113-114 (General)3) Gartel AL and Tyner AL, (2002) Mol Cancer Ther 1(8):639-649 (General)
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