anti-p38 MAPK, pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation and other signals. p38 MAPK is relatively inactive in the non-phosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor-alpha, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 and °6 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation. Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Alternate Names/Synonyms: CSBP; MAPK14; SAPK2a; MAPK 14; EC=2.7.11.24; MAP Kinase 14; MAP Kinase MXI2; MAP Kinase p38 alpha; CSAID-binding Protein; MAX-interacting Protein 2; Stress-activated Protein Kinase 2a

Product Type: Polyclonal Antibody

Immunogen: Synthetic glutaldehyde peptide (KLH coupled) corresponding to C-terminal residues of human p38 MAP kinase.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Rouse, J. et al. (1994) Cell, 78: 1027-1037. (General)2) Herlaar, E. and Brown, Z. (1999) Mol. Med. Today, 5(10): 439-447. (General)3) Martin-Blanco, E. (2000) BioEssays, 22(7): 637-645. (General)4) Olson, J.M. and Hallahan, A.R. (2004) Trends Mol. Med. 10(3): 125-129. (General)