anti-Paraoxonase 1, mAb (17A12)

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The paraoxonase(PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g. chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson°s disease. Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Alternate Names/Synonyms: PON; PON1; K-45; PON 1; EC=3.1.8.1; EC=3.1.1.2; EC=3.1.1.81; A-Esterase 1; Aromatic Esterase 1; Serum Aryldialkylphosphatase 1; Serum Paraoxonase/Arylesterase 1

Product Type: Monoclonal Antibody

Clone: 17A12

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-PON1 protein purified E. coli.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Akhmedova SN, et al. (2001) J Neurol Sci 184 (2):179-82. (General)2) Kondo I, et al. (1998) Brain Res 806(2):271-3. (General)