AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Polyclonal Antibody. Recognizes the Human, Mouse protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Platelet-derived growth factors (PDGFs) have been implicated in the control of cell proliferation, survival and migration. The PDGF family of growth factors consists of five different disulphide-linked dimers built up of four different polypeptide chains encoded by four different genes. Theses isoforms, PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD, act via two receptor tyrosine kinases, PDGF receptors alpha and beta. Thus far, gene-targeting experiments have been attempted to create knockout mice deficient for PDGFR-alpha or PDGFR-beta. Those mice, however, died either at the embryonic stage or several days after birth. Platelet-derived growth factor receptors, PDGFR-alpha and PDGFR-beta, have five extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo- and heterodimers. Dimerization of the receptors juxtaposes the intracellular part of the receptors, which allow phosphorylation in trans between the two receptors in the complex. These autophosphorylation provide docking sites for downstream signal transduction molecules. More than 10 different SH2°domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF alpha- and beta-receptors. There are signal transduction molecules with enzymatic activity, such as PI3-kinase, PLC-gamma, Src, SHP-2, GAP, as well as adaptor molecules such as Grb2, Shc, Nck, Grb7 and Crk, and Stats. Each of the different partners recruited by the activated receptor initiates different signaling pathways, making possible a great variety of cellular response. Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.
Product Type: Polyclonal Antibody
Immunogen: Synthetic phospholyrated peptide (KLH coupled) corresponding to residues surrounding Tyr 857 of human PDGF Receptor beta.
Species Crossreactivity: Human, Mouse
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Heldin, CH. et al. (1998) Biochim. Biophys. Acta, 1378(1), F79-F113. (General)2) Claesson-Welsh, L. (1994) J. Biol. Chem. 269(51), 32023-32026. (General)3) Soriano, P. (1997) Development, 124, 2691-2700. (General)4) Soriano, P. (1994) Genes Dev. 8, 1888-1896. (General)
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