Peroxiredoxin 3 (human) (rec.)

Product Description: Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 4 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol (1).

Alternate Names/Synonyms: AOP1; AOP-1; PRDX3; HBC189; Prx-III; EC=1.11.1.15; Peroxiredoxin-3; Peroxiredoxin III; Protein MER5 Homolog; Antioxidant Protein 1; Thioredoxin-dependent Peroxide Reductase, Mitochondrial

Product type: Protein

Source / Host: E. coli

Species Crossreactivity: Human

Biological Activity: 1.2U/mg (One unit will cause the oxidation of 1.0 µmole of NADPH at 25°C at pH7.5)

Purity: >95% (SDS-PAGE)

Concentration: 1 mg/ml

Formulation: Liquid in 20mM HEPES, pH 7.0, 10% Glycerol.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: -20°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability:

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