anti-Peroxiredoxin 3 (mouse), mAb (AF17D2FF)

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology particularly amino terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 6 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol. Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system.

Alternate Names/Synonyms: Aop1; AOP-1; Prdx3; PRX III; EC=1.11.1.15; Protein MER5; Perioredoxin-3; Antioxidant Protein 1; Thioredoxin-dependent Peroxide Reductase, Mitochondrial

Product Type: Monoclonal Antibody

Clone: AF17D2FF

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human GST-mPrx3 protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Wood ZA et al. (2003) Trends Biochem Sci 28(1) ;32-40. (General)