anti-Peroxiredoxin 4, mAb (1A1)

Product description: Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 – 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 6 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol (1). Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

Alternate Names/Synonyms: PRDX4; Prx-IV; AOE37-2; EC=1.11.1.15; Peroxiredoxin-4; Peroxiredoxin IV; Antioxidant Enzyme AOE372; Thioredoxin Peroxidase AO372; Thioredoxin-dependent Peroxide Reductase A0372

Product Type: Monoclonal Antibody

Clone: 1A1

Isotype: Mouse IgG3 kappa

Immunogen: Recombinant human fragment protein (without secretion leader sequence) purified from E. coli.

Applications: IP

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. (General)