Peroxiredoxin 4 (Prdx4) (human) ELISA Kit (4x96T)

Product description: Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 4 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol (1).

Alternate Names/Synonyms: PRDX4; Prx-IV; AOE37-2; EC=1.11.1.15; Peroxiredoxin-4; Peroxiredoxin IV; Antioxidant Enzyme AOE372; Thioredoxin Peroxidase AO372; Thioredoxin-dependent Peroxide Reductase A0372

Product Type: Kit

Crossreactivity: Human

Sensitivity: 6.77 pg/ml

Range: 0.078 ng/ml - 5 ng/ml

Sample Type: Human Serum, Plasma, Cell Lysate Buffered Solution

Assay Type: Sandwich

Detection Type: Colorimetric

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Handling Advice Any unused reconstituted standard should be discarded or frozen at -80°C. Standard can be frozen and thawed one time only without loss of immunoreactivity.

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