anti-PGRP-L, mAb (45G1)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that recognize bacteria and their unique cell wall component, peptidoglycan (PGN). Mammals have four PGRPs, designated in humans PGRP-S(24kDa), PGRP-L(60~65kDa), PGRP-Ialpha(38kDa), and PGRP-Ibeta(44kDa). Human PGRPs are differentially expressed in various tissues and organs: PGRP-S mainly in the bone marrow and Polymorphonuclear leukocyte (PMNs), PGRP-L mainly in the liver, and PGRP-Ia and PGRP-Ib mainly in the esophagus. The function of only one mammalian PGRP, PGRP-S, is currently known. Mouse PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Alternate Names/Synonyms: PGRP-L; PGLYRPL; PGLYRP2; EC=3.5.1.28; N-Acetylmuramoyl-L-Alanine Amidase; Peptidoglycan Recognition Protein 2; Peptidoglycan Recognition Protein Long

Product Type: Monoclonal Antibody

Clone: 45G1

Isotype: Mouse IgG1 kappa

Immunogen: Peptidoglycan recognition protein (PGRP)-L purified form human protein.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Zheng-Ming Wang et. al. (2003) J Biol Chem 278 (49): 49044-49052. (General)2) Chao Liu et. al. (2001) J Biol Chem 276(37): 34686-34694. (General)