anti-Phospho-Stat3 (Y705), pAb

Product description: Polyclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Signal transducer and activator of transcription (STAT), named after their dual role, are latent cytoplasmic transcription factors that mediate various biological responses. The activation of STAT proteins is largely mediated by phosphorylation of C-terminal transactivation domain through Janus kinases (JAKs) and mitogen-activated protein kinases (MAPKs), which allows the activated STATs to dimerize and to translocate into the nucleus. By modulating target gene expression, STAT proteins play an important role in mediating a broad range of biological processes such as cell proliferation, survival, apoptosis, and differentiation. Seven mammalian members of the STAT family are known (STAT1, 2, 3, 4, 5a, 5b, and 6) and they all share common features and structure. STAT3 is activated by growth factors and oncogenic kinases where it mediates transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis. Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Alternate Names/Synonyms: APRF; STAT3; Acute-phase response Factor; Signal Transducer and Activator of Transcription 3

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique

Literature References: 1) Aggarwal BB, et al, Ann N Y Acad Sci. 2006; vol.1091: p.151-69. (General)2) Gao SP, Bromberg JF. Sci STKE. 2006; vol.2006(343): pe30. (General)3) Inghirami G, et al, Cell Cycle. 2005; vol.4(9): p.1131-3. (General)4) Jing N, Tweardy DJ. Anticancer Drugs. 2005; vol.16(6): p.601-7. (General)