AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Polyclonal Antibody. Recognizes the Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Protein kinase C (PKC) is a family of serine-threonine kinases that regulate a broad spectrum of cellular functions such as cell migration and polarity, proliferation, differentiation, and cell death. The family is composed of several genes that express structurally related phospholipid-dependent kinases with distinct means of regulation and tissue distribution. Based on their structures and sensitivities to Ca2+ and diacylglycerol (DAG), they have been classified into conventional PKCs (alpha, beta, and gamma), novel PKCs (delta, epsilon, ?, and ?), and atypical PKCs (? and ?/?). PKCs share a structural backbone, mainly consisting of a regulatory domain at the N-terminus and a catalytic domain at the C-terminus. All family members require phosphatidylserine, a component of the phospholipid bilayer, for their activation. Some PKCs (PKCalpha, delta, and ?) are widely expressed in all tissues, but other isoforms are expressed in a tissue-specific manner. PKCgamma, for example, is largely confined to brain and neuronal tissue, PKC? is mainly expressed in testis and insulin secreting cells, and PKC? is mainly expressed in skeletal muscle. PKC epsilon (PKCepsilon) is a calcium-independent and phorbolester/diacylglycerol-sensitive serine/threonine kinase. PKCepsilon is the only PKC isozyme that has been shown to behave as an oncoprotein. Constitutive activation of PKCepsilon in a small cell lung cancer (SCLC) cell line and the overexpression of PKCepsilon in colonic epithelial cells have been reported. This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Alternate Names/Synonyms: Pkce; Prkce; nPKC-epsilon; EC=188.8.131.52; Protein Kinase C epsilon Type
Product Type: Polyclonal Antibody
Immunogen: Synthetic peptide.
Species Crossreactivity: Mouse, Rat
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Breitkreutz D. et al. (2007) J Cancer Res Clin Oncol. 133:793-808. (General)2) Basu A. and Sivaprasad U. (2007) Cell Sinal. 19:1633-1642. (General)3) Akita Y. (2002) J Biochem (Tokyo) 132:847-852. (General)4) Nishizuka Y. (1995) FASEB J. 9:484-496. (General)
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