anti-PKC gamma (Protein Kinase C gamma), pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Protein kinase C (PKC) is a family of serine-threonine kinases that regulate a broad spectrum of cellular functions. The family is composed of nine genes that express structurally related phospholipid-dependent kinases with distinct means of regulation and tissue distribution. Based on their structures and sensitivities to Ca2+ and diacylglycerol (DAG), they have been classified into conventional PKCs (alpha, beta, and gamma), novel PKCs (delta, epsilon, ?, and ?), and atypical PKCs (? and ?/?). PKC gamma is a member of the cPKC subfamily which is activated by Ca2+ and diacylglycerol in the presence of phosphatidylserine. Physiologically, PKC gamma is activated by a mechanism coupled with receptor-mediated breakdown of inositol phospholipid as other cPKC isotypes. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons. Within the brain, PKC gamma is the most abundant in the cerebellum, hippocampus and cerebral cortex, where the existence of neuronal plasticity has been demonstrated. This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Alternate Names/Synonyms: PKCG; PRKCG; PKC-gamma; EC=2.7.11.13; Protein Kinase C gamma Type

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Saito N, Shirai Y. J Biochem (Tokyo). 2002; vol.132(5): p.683-7. (General)2) Chou WH, Messing RO. Trends Cardiovasc Med. 2005; vol.15(2): p.47-51. (General)