AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Polyclonal Antibody. Recognizes the Human, Mouse protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Protein kinase C (PKC) is a family of serine-threonine kinases that regulate a broad spectrum of cellular functions. The family is composed of nine genes that express structurally related phospholipid-dependent kinases with distinct means of regulation and tissue distribution. Based on their structures and sensitivities to Ca2+ and diacylglycerol (DAG), they have been classified into conventional PKCs (alpha, beta, and gamma), novel PKCs (delta, epsilon, ?, and ?), and atypical PKCs (? and ?/?). A novel serine-threonine kinase of the protein kinase C (PKC) family has been described and designated as PKC? (PKC nu) which has two putative diacylglycerol binding C1 domains. PKC? is abundantly expressed in human beta-cells, and it is a downstream effector for BCR (B-cell antigen receptor)-mediated DAG production. The closest homologues of PKC? are PKD1/PKCµ and PKD2, and together these three kinases form a distinct protein kinase subfamily. They share a predicted tertiary structure that includes two C1 domains contained in their amino-terminal halves, a single central pH domain, and closely homologous kinase domains in their COOH-terminal halves. Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.
Alternate Names/Synonyms: EPK2; PRKD3; nPKC-nu; EC=22.214.171.124; Protein Kinase EPK2; Protein Kinase C nu Type; Serine/Threonine-Protein Kinase D3
Product Type: Polyclonal Antibody
Immunogen: Synthetic peptide.
Species Crossreactivity: Human, Mouse
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Matthews S.A. et al. (2003) J Biol Chem. 278:9086-9091. (General)2) Nakashima, S. (2002) J Biochem (Tokyo). 132:669-675. (General)3) Saito N. and Shirai Y. (2002) J Biochem (Tokyo). 132:683-687. (General)4) Hayashi, A. et al. (1999) Biochim Biophys Acta. 1450:99-106. (General)
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