anti-PLC gamma, mAb (1F1)

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The mammalian Phospholipase C (PLC) family has two closely related proteins, PLC1 and PLC2. The PLC isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCgamma. Activated PLC catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

Alternate Names/Synonyms: PLC1; PLCG1; PLC-II; PLC-148; EC=3.1.4.11; PLC-gamma-1; Phospholipase C-II; Phospholipase C-gamma-1; Phosphoinositide Phospholipase C-gamma-1; 1-Phosphatidylinositol 4;5-Bisphosphate PhosphodiEsterase gamma-1

Product Type: Monoclonal Antibody

Clone: 1F1

Isotype: Mouse IgG2a kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique

Literature References: 1) Katan, M. (1998) Biochim. Biophys. Acta, 1436, 5-17. (General)2) Singer, W.D. et al. (1997) Annu. Rev. Biochem. 66, 475-509. (General)3) Wang, Z. et al. (1998) Mol. Cell. Biol. 18, 590-597. (General)