anti-Protein Tyrosine Phosphatase 1B, mAb (3A7)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. In vivo, tyrosine phosphorylation is reversible and dynamic and the phosphorylation states are governed by the opposing activites of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). PTPs are involved in controlling of diverse array of cellular process. They are large(~100) and structurally diverse family of enzymes. PTPs contain one or two catalytic domains which is approximately 280 residues and are characterized by the existence of the signature motif HC(X)5R. The Cys and Arg residues in this motif have essential functions for catalytic activity. PTPs regulate cell growth and metabolism, with special emphasis on its ability to regulate integrin, growth factor, and cytokine signaling. May play an important role in CKII- and p60c-src-induced signal transduction cascades

Alternate Names/Synonyms: PTP1B; PTPN1; PTP-1B; EC=3.1.3.48; Protein-Tyrosine Phosphatase 1B; Tyrosine-Protein Phosphatase Non-Receptor Type 1

Product Type: Monoclonal Antibody

Clone: 3A7

Isotype: Mouse IgG2a kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Tonks, N.K. (2003) FEBS Lett. 546(1), 140-148. (General)2) Zhang, Z.Y. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 209-234. (General)3) Neel, B.G. and Tonks, N.K. (1997) Curr. Opin. Cell. Biol. 9, 193-204. (General)