AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Receptor-type tyrosine-protein phosphatase eta (also known as DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA) is an enzyme that in humans is encoded by the PTPRJ gene [1-3]. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction . PTPRJ has been shown to interact with CTNND1 . Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
Alternate Names/Synonyms: DEP1; PTPRJ; CD148; DEP-1; R-PTP-J; HPTP eta; R-PTP-eta; EC=126.96.36.199; Density-enhanced Phosphatase 1; Protein-Tyrosine Phosphatase eta; Protein-Tyrosine Phosphatase Receptor type J
Product Type: Monoclonal Antibody
Isotype: Mouse IgG2b
Immunogen: Recombinant human protein purified from E. coli.
Species Crossreactivity: Human
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Ostman A, et al. (1994), "Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density". Proc Natl Acad Sci U S A 91 (21): 96804. (General)2) Honda H, et al. (1995), "Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta". Blood 84 (12): 418694. (General)3) "Entrez Gene: PTPRJ protein tyrosine phosphatase, receptor type, J (General)4) Holsinger, LJ, et al. (2002), "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene (England) 21 (46): 706776. (General)
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