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100 µl

Ref. YIF-LF-MA0304
AB Frontier

photos non contractuelles

Neuf 309.00 H.T.


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Détails Produit

Product description: Receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT) is a transmembrane protein that is highly expressed in the developing and adult central nervous system. It is a member of the RPTP R2B subfamily, which includes PTPkappa, PTPµ and PCP-2. The R2B phosphatases are known to interact with members of the cadherin/catenin complex. These four RPTPs share the same domain structure: an extracelluar domain, a juxtamembrane region, and two phosphatase domains. The extracellular domain of PTPR mediates cell-cell aggregation and that mutational inactivation of this phosphatase could promote tumor migration and metastasis. PTPRT is the most frequently mutated PTP in human cancers. STAT3 is a substrate of PTPRT. Phosphorylation of a tyrosine at 705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. May be involved in both signal transduction and cellular adhesion in the CNS.

Alternate Names/Synonyms: PTPRT; R-PTP-T; RPTP-rho; KIAA0283; EC=; Receptor-type Tyrosine-Protein Phosphatase T; Receptor-type Tyrosine-Protein Phosphatase rho

Product Type: Monoclonal Antibody

Clone: AFT20

Isotype: Mouse IgG2a kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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