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100 µl

Ref. YIF-LF-MA0345
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Receptor protein tyrosine phosphatase rho (RPTP?/PTPRT) is a transmembrane protein that is highly expressed in the developing and adult central nervous system. It is a member of the RPTP R2B subfamily, which includes PTPkappa, PTP? and PCP-2. The R2B phosphatases are known to interact with members of the cadherin/catenin complex. These four RPTPs share the same domain structure: an extracelluar domain, a juxtamembrane region, and two phosphatase domains. The extracellular domain of PTPR mediates cell-cell aggregation and that mutational inactivation of this phosphatase could promote tumor migration and metastasis. PTPRT is the most frequently mutated PTP in human cancers. STAT3 is a substrate of PTPRT. Phosphorylation of a tyrosine at 705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. May be involved in both signal transduction and cellular adhesion in the CNS.

Alternate Names/Synonyms: PTPRT; R-PTP-T; RPTP-rho; KIAA0283; EC=3.1.3.48; Receptor-type Tyrosine-Protein Phosphatase T; Receptor-type Tyrosine-Protein Phosphatase rho

Product Type: Monoclonal Antibody

Clone: T20-AF3C7

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Yu J et al. (2008) Mol Cancer Res 6(7):1106-13. (General)2) Zhang X et al. (2007) Proc Natl Acad Sci 104(10):4060-4. (General)3) Besco JA et al. (2006) Brain Res 1116(1):50-7. (General)