anti-Retinol Binding Protein (20F9)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Retinol binding protein (RBP), a 21kDa single-chain glycoprotein, is the primary plasma transport protein for retinol (vitamin A1). RBP solubilizes the water-insoluble retinol and works as a vehicle for transport to the target organs, and it may also protect the bound retinol from oxidative damage in the plasma. The circulating RBP binds to another protein called transthyretin (TTR), a 55-kDa plasma thyroxine binding protein. Such protein-protein complex formation is thought to prevent glomerular filtration of low molecular mass RBP. Serum levels of RBP are useful in the detection of liver disease, protein-calorie malnutrition, and vitamin A deficiencies. In addition, the determination of RBP serum levels has been shown to be important in the mediation of antitumor effects. Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Alternate Names/Synonyms: RBP4; PRO2222

Product Type: Monoclonal Antibody

Clone: 20F9

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Zanotti G, Berni R. Vitam Horm. (2004) vol.69: pp.271-95. (General)2) Newcomer ME, Ong DE. Biochim Biophys Acta. (2000) vol.1482: pp.57-64. (General)3) Raghu P, Sivakumar B. Biochim Biophys Acta. (2004) vol.1703: pp.1-9. (General)