anti-RIP2, mAb (AF28D3)

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The RIP (receptor-interacting protein) family of serine/Threonine kinases (RIP-1,2,3,4,5,6,7) are crucial regulators of cell survival and cell death that can trigger pro-survival, inflammatory and immune responses via the activation of transcription factors(NF-kappaB and AP-1) and death-inducing programs. RIP2(also known as RICK, CARDIAK, CCK and Ripk2) transduces signals from receptors of both immune responses. RIP2 carries a CARD at its C-terminal, which is essential for NF-kappaB activation. RIP2 is a critical downstream mediator of Nod1 and Nod2 signaling. Overexpression of RIP2 results in the activation of, in addition to NF-kappaB, the MAPKs JNK and ERK2, requiring its kinase activity to activate ERK2, but not JNK. Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappaB.

Alternate Names/Synonyms: RIP-2; RIPK2; CARDIAK; EC=2.7.11.1; EC=2.7.10.2; Tyrosine-Protein Kinase RIPK2; Receptor-interacting Protein 2; RIP-like-interacting CLARP Kinase; CARD-containing IL-1 beta ICE-Kinase

Product Type: Monoclonal Antibody

Clone: AF28D3

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-RIP2 protein purified from E. coli.

Applications: ELISA, IP, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Kobayashi K et al. (2002) Nature 416, 194-199 (General)2) Hasegawa M, (2008) EMBO 27, 373–383 (General)3) Meylan E and Tschopp J, (2005) TRENDS in Biochem Sciences 30:151-159 (General)