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100 µl

Ref. YIF-LF-MA0183
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threon-ine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to -4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase dimains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphor-ylation of transcriptional regulators includ-ing c-Fos, estrogen receptor, NFkappaB/IkappaB alpha, cAMP-response element-binding protein (CREB). Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Alternate Names/Synonyms: RSK-1; p90S6K; p90RSK1; RPS6KA1; p90-RSK 1; MAPKAPK1A; MAPKAPK-1a; EC=2.7.11.1; S6K-alpha-1; MAPKAP Kinase 1a; Ribosomal S6 Kinase 1; MAPK-activated Protein Kinase 1a

Product Type: Monoclonal Antibody

Clone: 8C12

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-RSK1 protein purified from E. coli.

Applications: ELISA, IP, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Roux, P. P. et al. (2003) Mol Cell Biol. 23: 4796–4804. (General)2) Frodin, M. and Gammeltoft ,S. (1999) Mol Cell Endocrinol. 151:65-77. (General)3) Fisher, T. L. and Blenis, J. (1996) Mol. Cell. Biol. 16:1212-1219. (General)