anti-Tau, pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Tau proteins are microtubule-associated proteins that are abundant in neurons in the central nervous system. In adult human brain, there are six tau isoforms that differ by the presence of either three or four C-terminal tandem repeated 31 or 33 amino acid sequences containing domains that are important for microtubule binding. Tau plays a crucial role in the neuron as it binds and stabilizes microtubules, and can regulate axonal transport; functions that are regulated by site-specific phosphorylation events. Abnormally hyperphosphorylated Tau protein, resulting in loss of function (the disruption of axonal transport) and gain of toxic function (formation of tau aggregates) at the same time, is deposited in cells as fibrillar lesions in numerous neurodegenerative diseases such as Alzheimer's disease, progressive supranuclear palsy, Pick's disease, corticobasal degeneration and post-encephalitic parkinsonism. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Alternate Names/Synonyms: MAPT; MAPTL; PHF-tau; Paired Helical Filament-tau; Neurofibrillary Tangle Protein; Microtubule-associated Protein tau

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Wenning GK, Jellinger KA. Curr Opin Neurol. 2005; vol.18(4): p.357-62. (General)2) Lee HG, et al, Trends Mol Med. 2005; vol.11(4): p.164-9. (General)3) Shahani N, Brandt R. Cell Mol Life Sci. 2002; vol.59(10): p.1668-80. (General)4) Churcher I. Curr Top Med Chem. 2006; vol.6(6): p.579-95. (General)