AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Thyroglobulin (Tg) is a 660 kDa, dimeric protein consisting of two subunits containing 2750 amino acids with a molecular weight of 330 kDa. Among twenty putative N-linked glycosylation sites, only 16 are glycosylated in the mature protein. Tg is produced by and used entirely within the thyroid gland. Tg is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Iodinated Tg is stored in the lumen of thyroid follicles. Upon stimulation by thyroid stimulating hormone (TSH), Tg is reabsorbed into thyrocytes and degraded to end product T3 and T4 that are subsequently secreted into the bloodstream. Tg-specific antibodies help in the diagnosis of with Hashimoto's thyroiditis which is an autoimmune disease inducing hypothyroidism, or Graves° disease which is a thyroid disorder characterized by goitre, exophthalmos, and hyperthyroidism. Thyroid carcinoma developing from dyshormonogenic goiters due to Tg mutation have been reported. It has been suggested that constant and prolonged stimulation by TSH might result in the appearance of thyroid carcinoma. Tg levels in the blood can be used as a tumor marker for papillary and follicular thyroid cancer. Tg levels in the blood can also be elevated in cases of Graves' disease. TSH (Thyroid-stimulating hormone)-stimulated Tg test using a Tg cutoff of 2 µ g/liter is sufficiently sensitive to be used as the principal test in the follow-up management of low-risk patients with DTC (differentiated thyroid cancer). Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Alternate Names/Synonyms: Tg; TG; Thyroglobulin
Product Type: Monoclonal Antibody
Isotype: Mouse IgG1 kappa
Immunogen: Human protein.
Species Crossreactivity: Human
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Lin JD, (2008) Clin Chim Acta. 388(1-2):15-21. (General)2) Gupta M and Chia SY, (2007) Curr Opin Endocrinol Diabetes Obes. 14(5):383-388. (General)3) Mazzaferri EL et al. (2003) J Clin Endocrinol Metab. 88(4):1433-1441. (General)
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