anti-Transglutaminase 2, pAb

Product description: Polyclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Transglutaminase (TGase) catalyses the crosslink of proteins by forming epsilon-(gamma-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal beta-sandwich, catalytic core and two C-terminal beta-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer°s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Abeta peptide, beta-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Alternate Names/Synonyms: TGC; TGM2; TG(C); TGase H; TGase-2; TGase C; EC=2.3.2.13; Transglutaminase-2; Transglutaminase H; Transglutaminase C; Tissue transglutaminase; Protein-Glutamine gamma-Glutamyltransferase 2

Product Type: Polyclonal Antibody

Immunogen: Recombinant human protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Griffin, M. et al. (2002) Biochem. J. 368, 377-396. (General)2) Fesus, L. and Piacentini, M. (2002) Trends. Biochem. Sci. 27(10), 534-539. (General)3) Kim, SY. et al. (2002) Neurochem. Int. 40, 85-103. (General)