anti-Transthyretin, pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Transthyretin (TTR), generally called prealbumin, is a plasma protein that plays an important role in physiology such as a transporter of hormone thyroxine and retinal-binding protein. After produced primarily in the liver, TTR is excreted into the plasma. TTR represents a disproportionate fraction (25%) of CSF protein, prompting the suggestion that it is either selectively transported across the blood-CSF barrier or synthesized de novo within the central nervous system. Transthyretin is a constituent found to the neuritic plaques, neurofibrillary tangles, and microangiopathic lesions of senile cerebral amyloid. It has been reported that more than 40 different mutations in the TTR gene associated with amyloid deposition. Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Alternate Names/Synonyms: TTR; TBPA; ATTR; PALB; Prealbumin; Transthyretin

Product Type: Polyclonal Antibody

Immunogen: Recombinant human protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Hamilton, J.A. and Benson, M.D. (2001) Cell. Mol. Life Sci. 58, 1491-1521. (General)2) Shirahama, T. et al. (1982) Am. J. Path. 107, 41-50. (General)3) Episkopou, V. et al. (1993) Proc. Nat. Acad. Sci. 90, 2375-2379. (General)4) Saraiva, M.J.M. (1995) Hum. Mutat. 5, 191-196. (General)5) Pfeffer, B. et al. (2004) Mol. Vis. 10, 23-30. (General)