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10x96 wells

Ref. YIF-LF-EK0183
AB FRONTIER

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Neuf 5170.00 H.T.

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Détails Produit

Product description: Transthyretin (TTR, 55 kDa homotetramer) is a thyroid hormone-binding protein that transports thyroxine (T4) from the bloodstream to the brain. TTR was originally called prealbumin because it ran faster than albumin on electrophoresis gels. TTR is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine. TTR is suggested that plays an essential role in brain function. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain. TTR is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC). Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Alternate Names/Synonyms: TTR; PALB; TBPA; ATTR; Prealbumin; Transthyretin

Product Type: Kit

Crossreactivity: Human

Sensitivity: 0.24 ng/ml

Range: 0.46 ng/ml - 30 ng/ml

Sample Type: Human Serum, Plasma, Cell Lysate Buffered Solution

Assay Type: Sandwich

Detection Type: Colorimetric

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Handling Advice Any unused reconstituted standard should be discarded or frozen at -80°C. Standard can be frozen and thawed one time only without loss of immunoreactivity.

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Manuel Kit