AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product Description: Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic pro-inflammatory cytokine produced mainly by activated macrophages and in smaller amounts by several other types of cell. TNF-alpha has been isolated and characterized from a large number of mammals and fish species. TNF-alpha is expressed in two different forms: a soluble. Mature 17kDa form and a transmembrane 26kDa form. TNF-alpha interacts with two distinct cell-surface receptors, Tumor necrosis factor receptor 1 (TNFR1) and TNFR2. these mediate the cellular actions. The actions of TNF-alpha are diverse and profound involving inflammation, apoptosis, cell proliferation and the stimulation of various aspects within the immune system. TNF-alpha is increasingly recognized as a key regulator of lipid metabolism in adipose tissue and protein catabolism in muscle and in disease states such as cancer, Acquired Immune Deficiency Syndrome (AIDS) and obesity-related insulin resistance.
Alternate Names/Synonyms: TNF; TNFA
Product type: Protein
Source / Host: E. coli
Species Crossreactivity: Human
Biological Activity: The ED50 as determined by the cytolysis of murine L929 cells in the presense of actinomycin D is 0.03-0.06 ng/ml.
Purity: >98% (SDS-PAGE)
Formulation: Liquid in 20mM Tris, pH 8.0, 1mM EDTA, 10% Glycerol.
Handling Advice: Avoid freeze/thaw cycles.
Short Term Storage: -20°C
Long Term Storage: -80°C
Shipping: DRY ICE
Use & Stability: After reconstitution, store at -80°C.
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