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0.5 mg

Ref. YIF-LF-P0042
AB FRONTIER

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Neuf 226.00 H.T.

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Détails Produit

Product Description: Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub+1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration.

Alternate Names/Synonyms: UBB; Frameshift

Product type: Protein

Source / Host: E. coli

Species Crossreactivity: Human

Purity: >95% (SDS-PAGE)

Concentration: 1 mg/ml

Formulation: Liquid in 20mM HEPES, pH7.0, 10% Glycerol.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: -20°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability:

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