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100 µl

Ref. YIF-LF-PA0155
AB FRONTIER

photos non contractuelles

Neuf 331.00 H.T.

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Détails Produit

Product description: Polyclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Voltage-dependent anion channel(VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC contitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity. Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Alternate Names/Synonyms: VDAC; VDAC1; hVDAC1; VDAC-1; Porin 31HM; Porin 31HL; Plasmalemmal Porin; Outer Mitochondrial Membrane Protein Porin 1; Voltage-dependent Anion-selective Channel Protein 1

Product Type: Polyclonal Antibody

Immunogen: Synthesis peptide (KLH coupled) corresponding to C-terminal residues of Human VDAC1.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Hinsch KD, et al.(2004) J. Biol. Chem. 279(15):15281-8. (General)2) Liberatori S, et al.(2004) Proteomics, 4(5):1335-40. (General)3) Alfons Lawen, et al.(2005) Int J Biochem Cell Biol. 37(2):277-82. (General)4) Mark A. Baker, et al.(2004) J. Biol. Chem. 279(6):4811-4819. (General)