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50 µg

Ref. SBB-PP0005-C050
SOUTH BAY BIO

photos non contractuelles

Neuf 158.00 H.T.

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Détails Produit

Product Description: The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or the rapid turnover of misfolded proteins. One of the most important proteases in this pathway is the 26S proteasome, an ATP-dependent proteolytic complex, which is formed by the association of the barrel-shaped 20S proteasome (700kDa) and two 19S (700kDa) regulatory complexes. The 20S catalytic core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha-subunits and 2 rings are composed of 7 beta-subunits. The 20S catalytic core is able to degrade a variety of peptide substrates and poly-ubiquitinated proteins involved with apoptosis, DNA repair, endocytosis and cell cycle control.

Product type: Protein

Source / Host: Human Erythrocytes

Sequence: Human 20S Proteasome.

Species Crossreactivity: Human

Molecular Weight: ~700kDa

Purity: >95% (SDS-PAGE)

Concentration: Lot dependent.

Formulation: Liquid. In 50mM HEPES pH 7.6, 100mM sodium chloride, 1mM DTT.

Handling Advice: Aliquot to avoid freeze/thaw cycles.

Short Term Storage: -80°C

Long Term Storage: -80°C

Shipping: DRY ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

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