8-OHdG Check ELISA Kit (High Sensitivity)

Product description: 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals (incl. singlet oxygen and direct photodynamic action) that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer’s disease. 8-OHdG is popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA and can be detected in tissue, serum, urine and other biomaterials.

Alternate Names/Synonyms: 8-hydroxy-2' -deoxyguanosine

Product Type: Kit

Specificity: Specific for 8-OHdG. Has been tested to 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG,8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G).

Crossreactivity: All

Range: 0.125 to 10 ng/mL

Sample Type: Plasma, Serum, Urine

Assay Type: Competitive

Detection Type: Colorimetric

Other data: This ELISA Kits works also for DNA extracted from cultured cells or tissues. Detection Guide for Serum/Plasma http://www.jaica.com/e/8ohdg_serum.html Detection Guide for tissue samples or cultured cells http://www.jaica.com/e/8ohdg_tissue.html

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Use & Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.

Handling Advice Do not freeze.

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