AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals (incl. singlet oxygen and direct photodynamic action) that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimers disease. 8-OHdG is popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA and can be detected in tissue, serum, urine and other biomaterials.
Alternate Names/Synonyms: 8-hydroxy-2' -deoxyguanosine
Product Type: Kit
Specificity: Specific for 8-OHdG. Has been tested to 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG,8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G).
Range: 0.5 to 200 ng/mL
Sample Type: Urine
Assay Type: Competitive
Detection Type: Colorimetric
Other data: This ELISA Kit is suitable for urine and serum samples from animal and human. However, for human serum, tissue and cultured cells, we recommend 8-OHdG Check ELISA Kit (High Sensitivity) (JAI-KOG-HS10E). Detection Guide for Serum/Plasma http://www.jaica.com/e/8ohdg_serum.html Detection Guide for Urine http://www.jaica.com/e/8ohdg_urine.html
Short Term Storage: +4°C
Long Term Storage: +4°C
Shipping: BLUE ICE
Use & Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Handling Advice Do not freeze.
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