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100 mg

Ref. SYN-1001-M100
SYNKINASE
852808-04-9

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Neuf 1083.00 H.T.
en stock

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Détails Produit

Product description: Chemical. CAS: 852808-04-9. Formula: C42H45ClN6O5S2. MW: 813.4. ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki <1 nM) and also shows a very high specificity over Mcl-1 and A1.

Alternate Names/Synonyms: ABT737

Product Type: Chemical

Molecular Formula: C42H45ClN6O5S2

Molecular Weight: 813.4

CAS: 852808-04-9

Purity: >95%

InChiKey: HPLNQCPCUACXLM-PGUFJCEWSA-N

Appearance: Solid.

Solubility: Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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