Angiopoietin-2 (mouse) (rec.)

Product description: Protein. Mouse angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.05EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS with trehalose and Brij35. Binds to the human and mouse Tie-2 receptor. Purity: >95% (SDS-PAGE). Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.

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