anti-BAFF (mouse), mAb (blocking) (Sandy-2) (preservative free)

Product description: Monoclonal Antibody. Recognizes mouse BAFF. Isotype: Mouse IgG1. Clone: Sandy-2. Applications: FUNC (Blocking), IP. Liquid. In PBS containing 10% glycerol. BAFF is a master regulator of peripheral B cell survival and, together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

Alternate Names/Synonyms: BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B

Product Type: Monoclonal Antibody

Clone: Sandy-2

Isotype: Mouse IgG1

Immunogen: Recombinant mouse BAFF.

Labels - Conjugates: Preservative Free

Applications: FUNC (Blocking), IP

Species Crossreactivity: Mouse

Specificity: Recognizes mouse BAFF.

Purity: >95% (SDS-PAGE)

Endotoxin: <0.01EU/µg purified protein (LAL test; Lonza).

Concentration: 1mg/ml

Formulation: Liquid. In PBS containing 10% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis: T. Abe, et al.; J. Immunol. 195, 1427 (2015) | Antibodies that block or activate mouse B cell activating factor of the TNF family (BAFF) respectively induce B cell depletion or B cell hyperplasia: C. Kowalczyk-Quintas, et al.; J. Biol. Chem. 291, 19826 (2016)