anti-CAIX (CA9), Rabbit Monoclonal (RM486)

Product description: Recombinant Antibody. This antibody reacts to human CAIX (CA9) (Carbonic Anhydrase 9). Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the C-terminus of human CAIX (CA9) (Carbonic Anhydrase 9). Applications: IHC, WB. Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CAIX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CAIX results in increased cell death under hypoxia. Therefore, CAIX has become a reliable histochemical marker of hypoxia.

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