anti-Caspase-1 (p20) (human), mAb (Bally-1) (Biotin)

Product description: Monoclonal Antibody. Recognizes endogenous full-length and activated (p20 fragment) human caspase-1. Isotype: Mouse IgG1. Clone: Bally-1. Applications: WB. Liquid. In PBS containing 0.02% sodium azide. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

Alternate Names/Synonyms: Interleukin-1 beta Convertase; IL-1BC; Interleukin-1 beta-converting Enzyme; ICE

Product Type: Monoclonal Antibody

Clone: Bally-1

Isotype: Mouse IgG1

Immunogen: Recombinant human caspase-1.

Labels - Conjugates: Biotin

Applications: WB

Species Crossreactivity: Human

Specificity: Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.

Purity: >95% (SDS-PAGE)

Concentration: 0.5mg/ml

Formulation: Liquid. In PBS containing 0.02% sodium azide.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells: V. Derangere, et al.; Cell Death Differ. 21, 1914 (2014) | Human monocytes engage an alternative inflammasome pathway: M.M. Gaidt, et al.; Immunity 44, 833 (2016)