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100 µg

Ref. AG-20B-0042B-C100

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Neuf 390.00 351.00 H.T.
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Détails Produit

Product description: Monoclonal Antibody. Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1. Isotype: Mouse IgG1. Clone: Casper-1. Applications: IHC, IP, WB. Liquid. In PBS containing 0.02% sodium azide. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

Alternate Names/Synonyms: Interleukin-1beta Convertase; IL-1BC; Interleukin-1beta-converting Enzyme; ICE;

Product Type: Monoclonal Antibody

Clone: Casper-1

Isotype: Mouse IgG1

Immunogen: Recombinant mouse caspase-1.

Labels - Conjugates: Biotin

Applications: IHC, IP, WB

Species Crossreactivity: Mouse

Specificity: Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.

Purity: >95% (SDS-PAGE)

Concentration: 0.5mg/ml

Formulation: Liquid. In PBS containing 0.02% sodium azide.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: Measuring the inflammasome: O. Gross; Methods Mol. Biol. 844, 199 (2012) | Inflammasome Activators Induce Interleukin-1alpha Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1: O. Gross, et al.; Immunity 36, 388 (2012) | Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation: Y. Yan, et al.; Immunity 38, 1154 (2013) | LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition: J. Jin, et al.; Nat. Commun. 4, 2075 (2013) | iGLuc: a luciferase-based inflammasome and protease activity reporter: E. Bartok, et al.; Nat. Methods 10, 147 (2013) | Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection: C. Lupfer, et al.; Nat. Immunol. 14, 480 (2013) | Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease: J.L. McAuley, et al.; PLoS Pathog. 9, e1003392 (2013) | Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop: C. Juruj, et al.; Front. Cell. Infect. Microbiol. 3, 14 (2013) | Inflammasome Activation by Altered Proteostasis: J.N. Shin, et al.; J. Biol. Chem. 288, 35886 (2013) | FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes: P. Gurung, et al.; J. Immunol. 192, 1835 (2014) | Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection: Md. H. Zaki, et al.; PNAS 111, 385 (2014) | XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation: M. Yabal, et al.; Cell Rep. 7, 1796 (2014) | The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014) | The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014) | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation: F. Madouri, et al.; J. Mol. Cell Biol. 7, 351 (2015)