anti-Caspase-8 (human), mAb (C15)

Product description: Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p18, respectively, which leads to the generation of the active caspase-8 heterotetramer (p18/p10)2.

Alternate Names/Synonyms: Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like Protease

Product Type: Monoclonal Antibody

Clone: C15

Isotype: Mouse IgG2b

Immunogen: Recombinant human caspase-8 (aa 181-478).

Applications: ICC, IP, WB

Species Crossreactivity: Human

Specificity: Recognizes the p18 subunit of human caspase-8.

Concentration: 0.5 mg/ml

Formulation: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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