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100 ug

Ref. AG-20T-0138-C100
AdipoGen Life Sciences

photos non contractuelles

Neuf 290.00 H.T.


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Détails Produit

Product description: Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.

Alternate Names/Synonyms: Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like Protease

Product Type: Monoclonal Antibody

Clone: 3B10

Isotype: Rat IgG1kappa

Immunogen: Recombinant mouse caspase-8 (p20 subunit).

Applications: ELISA, FACS, ICC, IHC, WB

Species Crossreactivity: Mouse

Specificity: Recognizes the p20 subunit of mouse caspase-8. Detects bands of ~55kDa (full-length caspase-8) and ~18kDa (apoptosis-induced cleavage fragment) by Western blot. Does not cross-react with human caspase-8.

Endotoxin: <0.1EU/µg purified protein (LAL test; Lonza).

Concentration: 1mg/ml

Formulation: Liquid. In PBS containing 0.02% sodium azide.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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